In cold chain warehousing and frozen logistics, maintaining reliable adhesion performance at temperatures of -20°C and below remains a critical challenge for pressure-sensitive adhesive (PSA) manufacturers. Conventional SIS-based adhesives often experience reduced tack, poor wetting ability, and adhesion instability under ultra-low temperature conditions, resulting in label failure, edge lifting, and packaging issues. By incorporating a high-flow, low-styrene SIS with optimized high-diblock molecular design into existing SIS/SSBR formulation systems, adhesive manufacturers can improve low-temperature flexibility, wetting performance, and bonding stability without requiring major changes to existing production processes. This article explores the material mechanisms behind cold-chain adhesion failures and how specialty SIS solutions can support the development of high-performance low-temperature PSA applications.