The hydrogenated styrene–butadiene–styrene block copolymer (SEBS)/Polypropylene (PP)-blended thermoplastic elastomer (TPE) is an ideal material for automotive interior skin applications due to its excellent elasticity, weather resistance, and environmentally friendly characteristics such as low odor and low volatile organic compounds (VOC). As a thin-wall injection-molded appearance skin product, it requires both high fluidity and good mechanical properties with scratch resistance. To optimize the performance of the SEBS/PP-blended TPE skin material, an orthogonal experiment and other methods were employed to investigate the impact of the formula composition and raw material characteristics, such as the styrene content and molecular structure of SEBS, on the TPE’s final performance. The outcomes revealed that the ratio of SEBS/PP had the most significant influence on the mechanical properties, fluidity, and wear resistance of the final products. The mechanical performance was enhanced by increasing the PP content within a certain range. The degree of sticky touch on the TPE surface was increased as the filling oil content increased, causing the increase in sticky wear and the decrease in abrasion resistance. When the SEBS ratio of high/low styrene content was 30/70, the TPE’s overall performance was excellent. The different proportions of linear/radial SEBS also had a significant effect on the final properties of the TPE. The TPE exhibited the best wear resistance and excellent mechanical properties when the ratio of linear-shaped/star-shaped SEBS was 70/30. https://www.x-mol.com/paper/1672013733976326144?adv